Van de Ven Double Ends The Toffees' Run at New Home Ground
Micky van de Ven became the initial backline player to score two goals in a Premier League game for Spurs since Jan Vertonghen in March 2013.
At a glance
The Spurs defender heads home two times in opening period
Everton's Jake O'Brien has equalizer ruled after video check
Pape Matar Sarr scores final goal in dying moments
This loss is the Merseyside club's initial at Hill Dickinson Stadium
Micky van de Ven scored on two occasions as Spurs prolonged their winning streak on the road in the Premier League and delivered Everton their initial loss at their new home.
Everton were unbeaten in their five previous fixtures at their new ground at Bramley-Moore Dock, having departed Goodison Park behind after more than a century at the end of last season.
But Spurs captain the Dutchman struck twice from set-pieces in the first half to place their impressive record at jeopardy, and they were unable to turn it around before the midfielder - assisted by ex-Everton forward the Brazilian - headed home a final goal to put the game to bed.
The Everton defender believed he had equalized the tally a short while after the defender's opener, directing a powerful header past the Spurs keeper from an Everton corner.
Beto, meanwhile, missed a handful of chances, while Vicario made a succession of fine saves to guarantee Tottenham went five matches on the road unbeaten in the English top flight.
But the VAR stepped in, instructing Craig Pawson to check the goal on the screen and the referee ruled that the winger and Iliman Ndiaye were in an illegal position and had interfered with the Tottenham goalkeeper.
This victory elevates Thomas Frank's side into third place in the Premier League, a handful of points off local foes and table-toppers Arsenal.
The Merseyside club remain in 14th position and are half a dozen points ahead of the relegation zone.
Spurs breakdown: The defender fulfils role at each end of pitch
After a drab midweek performance in the Champions League against Monaco, where they mustered a mere attempts on goal, the manager opted for Randal Kolo Muani in attack instead of former Toffees player Richarlison.
The new arrival was unable to influence the game before being replaced for the substitute after an hour on the field, but it turns out he proved unnecessary in the final outcome.
Centre-back Van de Ven transformed into an offensive threat to be feared.
Tottenham's first goal came from a cleverly executed set-piece play, with the midfielder directing the ball toward the six-yard box for an free Van de Ven to head home.
And the captain - stepping up as captain in Cristian Romero's unavailability - added his next goal in first-half stoppage time as he rose above the England keeper to head home.
The Dutchman was equally outstanding in defence, combining well with Kevin Danso as the pair dealt excellently with the 34 crosses thrown their way by the opposition.
Toffees breakdown: Toffees lacking striker's instinct
The club's recent stadium had been a happy hunting ground, but it seems the freshness may have faded somewhat and fans headed to the gates after the midfielder's final goal for Spurs.
The end in Everton's unbeaten home run will not be a major worry for David Moyes, but their striker situation will be.
Beto and Thierno Barry - the Toffees' pair of recognised centre-forwards - had netted only one league goal combined before the weekend's match.
And they were failed to contribute to that poor record on a damp and dreary night on Merseyside.
The striker's form was summed up when he chose to bicycle-kick a golden opportunity from close range, even with having room and time to reposition for a simpler shot that would have tested the keeper.
Barry, too, failed to influence the game after coming on for Beto in the 65th minute.
It was not for a lack of chance. The majority of the home side's attacks came through Grealish and Ndiaye, who relentlessly delivered threatening crosses into the Tottenham box.
Upcoming fixtures for both teams?
The Toffees: The team head to Sunderland in the top flight on early November at 20:00 GMT.
Tottenham: The London club travel to Newcastle's ground on Wednesday, 29 October for their next round Carabao Cup tie against the Magpies.